XBP1, CT (XBP1, TREB5, XBP2, X-box-binding protein 1, Tax-responsive element-binding protein 5)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

XBP1, CT (XBP1, TREB5, XBP2, X-box-binding protein 1, Tax-responsive element-binding protein 5)

catalog :

043913

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

043913

Product wo Prefix :

XBP1, CT (XBP1, TREB5, XBP2, X-box-binding protein 1, Tax-responsive element-binding protein 5)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

XBP1, TREB5, XBP2, X-box-binding protein 1, Tax-responsive element-binding protein 5

Immunogen :

XBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-252 amino acids from the C-terminal region of human XBP1.

Specificity :

Mouse

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: mouse Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: XBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-252 amino acids from the C-terminal region of human XBP1. Specificity: Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

Sudarshan, S.R., et al. Biochem. Biophys. Res. Commun. 399(4):617-622(2010) Thorpe, J.A., et al. Cell Stress Chaperones 15(5):497-508(2010) Bagratuni, T., et al. Blood 116(2):250-253(2010) Sawada, T., et al. J. Mol. Cell. Cardiol. 48(6):1280-1289(2010) Lee, J.H., et al. Exp. Mol. Med. 42(5):386-394(2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/34/043913_1.jpg