WAS, ID (WAS, IMD2, Wiskott-Aldrich syndrome protein) (AP) | US Biological 043803-AP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

WAS, ID (WAS, IMD2, Wiskott-Aldrich syndrome protein) (AP)

catalog :

043803-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

reactivity :

human

product information

Catalog Number :

043803-AP

Product wo Prefix :

WAS, ID (WAS, IMD2, Wiskott-Aldrich syndrome protein) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: Formalin-fixed, paraffin-embedded sections Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Hu Mo

Alternate Name :

WAS, IMD2, Wiskott-Aldrich syndrome protein

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 116-144 in the central region of human WAS.

Specificity :

Recognizes human WAS. Species Crossreactivity: mouse

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 116-144 in the central region of human WAS. Specificity: Recognizes human WAS. Species Crossreactivity: mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

4°C Do Not Freeze

Reference :

1. Rajmohan, R., et al. FEMS Yeast Res. 9(8):1226-1235(2009) 2. Dovas, A., et al. J. Cell. Sci. 122 (PT 21), 3873-3882 (2009) 3. Cammer, M., et al. J. Biol. Chem. 284(35):23302-23311(2009) 4. Zhang, J., et al. J. Biol. Chem. 284(32):21659-21669(2009) 5. Ameratunga, R., et al. N. Z. Med. J. 122(1304):46-53(2009)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/30/043803-AP_1.png