Vascular endothelial growth factor B, ID (VEGF2, VEGFB, VRF, Vascular endothelial growth factor B, VEGF-related factor)

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product summary

company name :

US Biological

product type :

antibody

product name :

Vascular endothelial growth factor B, ID (VEGF2, VEGFB, VRF, Vascular endothelial growth factor B, VEGF-related factor)

catalog :

043709

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

043709

Product wo Prefix :

Vascular endothelial growth factor B, ID (VEGF2, VEGFB, VRF, Vascular endothelial growth factor B, VEGF-related factor)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. VEGFB has structural similarities to VEGF and PIGF and is frequently co-expressed with VEGF. There are two alternatively spliced isoforms of VEGFB: VEGFB 167 and VEGFB 186. VEGFB 167, a highly basic heparin-binding protein, remains with the cell or extracellular matrix whereas, VEGFB 186 is readily secreted. VEGFB stimulates endothelial cell proliferation. VEGFB binds to the tyrosine kinase receptor VEGFR1 (flt1) and does not bind to VEGFR2. Vascular Endothelial Growth Factor B is widely expressed but is most abundant in heart, skeletal muscle, and pancreas. It has been suggested that VEGFB expression in human primary breast cancers is associated with lymph node metastasis. The genes that encode VEGFB have been mapped to chromosome 11q13. Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA Recommended Dilution: ELISA1:1,000 Western Blot1:50-100 Immunohistochemistry: 1:10-50 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

VEGF2, VEGFB, VRF, Vascular endothelial growth factor B, VEGF-related factor

Immunogen :

VEGFB (VEGF2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117~147 amino acids from the Center region of human VEGF2.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: VEGFB (VEGF2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117~147 amino acids from the Center region of human VEGF2. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

-20°C

Reference :

Trompezinski, S., et al., Exp. Dermatol. 13(2):98-105 (2004). Qi, J.H., et al., Nat. Med. 9(4):407-415 (2003). Joukov, V., et al., J. Cell. Physiol. 173(2):211-215 (1997). Olofsson, B., et al., J. Biol. Chem. 271(32):19310-19317 (1996). Olofsson, B., et al., Proc. Natl. Acad. Sci. U.S.A. 93(6):2576-2581 (1996).

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/7/043709_1.jpg