antibody

Vascular endothelial growth factor B, ID (VEGF2, VEGFB, VRF, Vascular endothelial growth factor B, VEGF-related factor) (AP)

043709-AP

200 ul

polyclonal

domestic rabbit

AP

Vascular endothelial growth factor B, ID (VEGF2, VEGFB, VRF, Vascular endothelial growth factor B, VEGF-related factor) (AP)

rabbit

Pab

AP

Antibodies

200 ul

IgG

Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. VEGFB has structural similarities to VEGF and PIGF and is frequently co-expressed with VEGF. There are two alternatively spliced isoforms of VEGFB: VEGFB 167 and VEGFB 186. VEGFB 167, a highly basic heparin-binding protein, remains with the cell or extracellular matrix whereas, VEGFB 186 is readily secreted. VEGFB stimulates endothelial cell proliferation. VEGFB binds to the tyrosine kinase receptor VEGFR1 (flt1) and does not bind to VEGFR2. Vascular Endothelial Growth Factor B is widely expressed but is most abundant in heart, skeletal muscle, and pancreas. It has been suggested that VEGFB expression in human primary breast cancers is associated with lymph node metastasis. The genes that encode VEGFB have been mapped to chromosome 11q13. Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA Recommended Dilution: ELISA1:1,000 Western Blot1:50-100 Immunohistochemistry: 1:10-50 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu

VEGF2, VEGFB, VRF, Vascular endothelial growth factor B, VEGF-related factor

VEGFB (VEGF2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117~147 amino acids from the Center region of human VEGF2.

Human

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: VEGFB (VEGF2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117~147 amino acids from the Center region of human VEGF2. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E IHC WB

4°C Do Not Freeze

Trompezinski, S., et al., Exp. Dermatol. 13(2):98-105 (2004). Qi, J.H., et al., Nat. Med. 9(4):407-415 (2003). Joukov, V., et al., J. Cell. Physiol. 173(2):211-215 (1997). Olofsson, B., et al., J. Biol. Chem. 271(32):19310-19317 (1996). Olofsson, B., et al., Proc. Natl. Acad. Sci. U.S.A. 93(6):2576-2581 (1996).

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