ULBP2, ID (ULBP2, N2DL2, RAET1H, NKG2D ligand 2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2) (APC) | US Biological 043592-APC product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

ULBP2, ID (ULBP2, N2DL2, RAET1H, NKG2D ligand 2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2) (APC)

catalog :

043592-APC

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

APC

reactivity :

human

product information

Catalog Number :

043592-APC

Product wo Prefix :

ULBP2, ID (ULBP2, N2DL2, RAET1H, NKG2D ligand 2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2) (APC)

Host :

rabbit

Product Type :

Pab

Conjugate :

APC

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. Applications: Suitable for use in Western Blot and FLISA. Other applications have not been tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

ULBP2, N2DL2, RAET1H, NKG2D ligand 2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 88-116 in the central region of human ULBP2.

Specificity :

Recognizes human ULBP2.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 88-116 in the central region of human ULBP2. Specificity: Recognizes human ULBP2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FL WB

Storage Temperature :

4°C Do Not Freeze

Reference :

1. McGilvray, R.W., et al. Int. J. Cancer 127(6):1412-1420(2010) 2. Nuckel, H., et al. Leukemia 24(6):1152-1159(2010) 3. Antoun, A., et al. Hum. Immunol. 71(6):610-620(2010) 4. Davila, S., et al. Genes Immun. 11(3):232-238(2010) 5. Ward, J., et al. PLoS Pathog. 5 (10), E1000613 (2009) :

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/27/043592-APC_1.png