antibody

TP63, CT (TP63, KET, P63, P73H, P73L, TP73L, Tumor protein 63, Chronic ulcerative stomatitis protein, Keratinocyte transcription factor KET, Transformation-related protein 63, Tumor protein p73-like, p40, p51) (AP)

043152-AP

200 ul

polyclonal

domestic rabbit

AP

TP63, CT (TP63, KET, P63, P73H, P73L, TP73L, Tumor protein 63, Chronic ulcerative stomatitis protein, Keratinocyte transcription factor KET, Transformation-related protein 63, Tumor protein p73-like, p40, p51) (AP)

rabbit

Pab

AP

Antibodies

200 ul

IgG

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu

TP63, KET, P63, P73H, P73L, TP73L, Tumor protein 63, Chronic ulcerative stomatitis protein, Keratinocyte transcription factor KET, Transformation-related protein 63, Tumor protein p73-like, p40, p51

TP63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 650-680 amino acids from the C-terminal region of human TP63.

Human

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: TP63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 650-680 amino acids from the C-terminal region of human TP63. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E WB

4°C Do Not Freeze

Du, Z., et al. Cancer Sci. 101(11):2417-2424(2010) Lena, A.M., et al. Biochem. Biophys. Res. Commun. 401(4):568-573(2010) Miki, D., et al. Nat. Genet. 42(10):893-896(2010) Yang, A., et al. PLoS ONE 5 (7), E11572 (2010) : Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :

https://usbio-images.r.worldssl.net/prodimages/21/043152-AP_1.jpg