TARDBP, NT (TARDBP, TDP43, TAR DNA-binding protein 43) | US Biological 042602 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

TARDBP, NT (TARDBP, TDP43, TAR DNA-binding protein 43)

catalog :

042602

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

042602

Product wo Prefix :

TARDBP, NT (TARDBP, TDP43, TAR DNA-binding protein 43)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is pr[sent on chromosome 20. Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:2000 Immunohistochemistry (FFPE): 1:100 Immunofluorescence: 1:10-1:50 Optimal dilutions to be detrmined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo

Alternate Name :

TARDBP, TDP43, TAR DNA-binding protein 43

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa1-30 in the N-terminal region of human TARDBP. Cellular Localization: Nucleus. Species Sequence Homology: chicken

Specificity :

Recognizes human TARDBP at ~45kD. Species Crossreactivity: mouse

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa1-30 in the N-terminal region of human TARDBP. Cellular Localization: Nucleus. Species Sequence Homology: chicken Specificity: Recognizes human TARDBP at ~45kD. Species Crossreactivity: mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IF IHC WB

Storage Temperature :

-20°C

Reference :

1. Kim, S.H., et al. J. Biol. Chem. 285(44):34097-34105(2010). 2. Geser, F., et al. Arch. Neurol. 67(10):1238-1250(2010). 3. Mackenzie, I.R., et al. Lancet Neurol 9(10):995-1007(2010). 4. Shan, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107(37):16325-16330(2010). 5. McKee, A.C., et al. J. Neuropathol. Exp. Neurol. 69(9):918-929(2010).

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/8/042602_1.jpg