STAT3, CT (STAT3, APRF, Signal transducer and activator of transcription 3, Acute-phase response factor) (AP) | US Biological 042383-AP product information

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product summary

company name :

US Biological

product type :

antibody

product name :

STAT3, CT (STAT3, APRF, Signal transducer and activator of transcription 3, Acute-phase response factor) (AP)

catalog :

042383-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

reactivity :

human

product information

Catalog Number :

042383-AP

Product wo Prefix :

STAT3, CT (STAT3, APRF, Signal transducer and activator of transcription 3, Acute-phase response factor) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

STAT3, APRF, Signal transducer and activator of transcription 3, Acute-phase response factor

Immunogen :

STAT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 673-699 amino acids from the C-terminal region of human STAT3.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: STAT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 673-699 amino acids from the C-terminal region of human STAT3. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Li, L., et al. Cancer Res. 70(20):8222-8232(2010) Takaishi, K., et al. Cancer Sci. 101(10):2128-2136(2010) Li, F., et al. Surgeon 8(5):262-266(2010) Schimke, L.F., et al. J. Allergy Clin. Immunol. 126(3):611-617(2010) Iliopoulos, D., et al. Mol. Cell 39(4):493-506(2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/47/042383-AP_1.jpg