SORD, ID (SORD, Sorbitol dehydrogenase, L-iditol 2-dehydrogenase) (AP) | US Biological 042141-AP product information

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product summary

company name :

US Biological

product type :

antibody

product name :

SORD, ID (SORD, Sorbitol dehydrogenase, L-iditol 2-dehydrogenase) (AP)

catalog :

042141-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

reactivity :

human

product information

Catalog Number :

042141-AP

Product wo Prefix :

SORD, ID (SORD, Sorbitol dehydrogenase, L-iditol 2-dehydrogenase) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

SORD, Sorbitol dehydrogenase, L-iditol 2-dehydrogenase

Immunogen :

SORD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-239 amino acids from the Central region of human SORD.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: SORD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-239 amino acids from the Central region of human SORD. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Szabo, Z., et al. Oncol. Rep. 23(5):1233-1239(2010) Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) : El-Kabbani, O., et al. Curr. Med. Chem. 11(4):465-476(2004) Pauly, T.A., et al. Structure 11(9):1071-1085(2003) Darmanin, C., et al. Acta Crystallogr. D Biol. Crystallogr. 59 (PT 3), 558-560 (2003) :

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/7/042141-AP_1.jpg