antibody

SFTPC, NT (SFTPC, SFTP2, Pulmonary surfactant-associated protein C, Pulmonary surfactant-associated proteolipid SPL(Val), SP5) (APC)

041642-APC

200 ul

polyclonal

domestic rabbit

APC

SFTPC, NT (SFTPC, SFTP2, Pulmonary surfactant-associated protein C, Pulmonary surfactant-associated proteolipid SPL(Val), SP5) (APC)

rabbit

Pab

APC

Antibodies

200 ul

IgG

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified. Applications: Suitable for use in Western Blot, Immunofluorescence and FLISA. Other applications not tested. Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Immunofluorescence: 1:10-50 Optimal dilution to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu Mo Rt

SFTPC, SFTP2, Pulmonary surfactant-associated protein C, Pulmonary surfactant-associated proteolipid SPL(Val), SP5

KLH-conjugated synthetic peptide corresponding to a fragment within amino acids 1-30 in the N-erminal region of human SFTPC, UniProt accession #P11686.

Recognizes human, mouse and rat SFTPC.

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A affinity chromatography. Immunogen: KLH-conjugated synthetic peptide corresponding to a fragment within amino acids 1-30 in the N-erminal region of human SFTPC, UniProt accession #P11686. Specificity: Recognizes human, mouse and rat SFTPC. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

FL IF WB

4°C Do Not Freeze

Wambach, J.A., et al. Pediatr. Res. 68(3):216-220(2010) Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010) Thouvenin, G., et al. Arch. Dis. Child. 95(6):449-454(2010) Crossno, P.F., et al. Chest 137(4):969-973(2010) Davila, S., et al. Genes Immun. 11(3):232-238(2010)

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