RANGAP1, NT (RANGAP1, KIAA1835, SD, Ran GTPase-activating protein 1) (APC) | US Biological 040827-APC product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

RANGAP1, NT (RANGAP1, KIAA1835, SD, Ran GTPase-activating protein 1) (APC)

catalog :

040827-APC

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

APC

reactivity :

human

product information

Catalog Number :

040827-APC

Product wo Prefix :

RANGAP1, NT (RANGAP1, KIAA1835, SD, Ran GTPase-activating protein 1) (APC)

Host :

rabbit

Product Type :

Pab

Conjugate :

APC

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. Applications: Suitable for use in Western Blot, Immunohistochemistry, FLISA Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

RANGAP1, KIAA1835, SD, Ran GTPase-activating protein 1

Immunogen :

RANGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-49 amino acids from the N-terminal region of human RANGAP1.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A affinity chromatography. Immunogen: RANGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-49 amino acids from the N-terminal region of human RANGAP1. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FL IHC WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Zhang, J., et al. Biochem. Biophys. Res. Commun. 375(2):252-255(2008) Zuccolo, M., et al. EMBO J. 26(7):1853-1864(2007) Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) : Vertegaal, A.C., et al. Mol. Cell Proteomics 5(12):2298-2310(2006) Vertegaal, A.C., et al. Mol. Cell Proteomics 5(12):2298-2310(2006)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/25/040827-APC_1.jpg