PTPRC, NT (PTPRC, CD45, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, T200, CD45)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

PTPRC, NT (PTPRC, CD45, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, T200, CD45)

catalog :

040667

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

040667

Product wo Prefix :

PTPRC, NT (PTPRC, CD45, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, T200, CD45)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq]. Applications: Suitable for use in Western Blot, Flow Cytometry and ELISA. Other applications have not been tested. Recommended Dilution: Western Blot: 1:1000 Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

PTPRC, CD45, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, T200, CD45

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 336-364 of human PTPRC.

Specificity :

Recognizes human PTPRC.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 336-364 of human PTPRC. Specificity: Recognizes human PTPRC. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E FC WB

Storage Temperature :

-20°C

Reference :

1. Heyd, F., et al. Mol. Cell 40(1):126-137(2010) 2. Wu, Z., et al. J. Immunol. 185(1):231-238(2010) 3. Cui, J., et al. Arthritis Rheum. 62(7):1849-1861(2010) 4. Booth, N.J., et al. J. Immunol. 184(8):4317-4326(2010) 5. Capitanescu, B., et al. Rom J Morphol Embryol 51(1):49-54(2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/12/040667_1.png