PTPRC, NT (PTPRC, CD45, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, T200, CD45) (AP) | US Biological 040667-AP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

PTPRC, NT (PTPRC, CD45, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, T200, CD45) (AP)

catalog :

040667-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

reactivity :

human

product information

Catalog Number :

040667-AP

Product wo Prefix :

PTPRC, NT (PTPRC, CD45, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, T200, CD45) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq]. Applications: Suitable for use in Western Blot and ELISA. Other applications have not been tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

PTPRC, CD45, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, T200, CD45

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 336-364 of human PTPRC.

Specificity :

Recognizes human PTPRC.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 336-364 of human PTPRC. Specificity: Recognizes human PTPRC. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

4°C Do Not Freeze

Reference :

1. Heyd, F., et al. Mol. Cell 40(1):126-137(2010) 2. Wu, Z., et al. J. Immunol. 185(1):231-238(2010) 3. Cui, J., et al. Arthritis Rheum. 62(7):1849-1861(2010) 4. Booth, N.J., et al. J. Immunol. 184(8):4317-4326(2010) 5. Capitanescu, B., et al. Rom J Morphol Embryol 51(1):49-54(2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/17/040667-AP_1.png