PTBP1, NT (PTBP1, PTB, Polypyrimidine tract-binding protein 1, 57kD RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I) (APC) | US Biological 040583-APC product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

PTBP1, NT (PTBP1, PTB, Polypyrimidine tract-binding protein 1, 57kD RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I) (APC)

catalog :

040583-APC

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

APC

reactivity :

human

product information

Catalog Number :

040583-APC

Product wo Prefix :

PTBP1, NT (PTBP1, PTB, Polypyrimidine tract-binding protein 1, 57kD RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I) (APC)

Host :

rabbit

Product Type :

Pab

Conjugate :

APC

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. Applications: Suitable for use in Western Blot, FLISA Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

PTBP1, PTB, Polypyrimidine tract-binding protein 1, 57kD RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I

Immunogen :

PTBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human PTBP1.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A affinity chromatography. Immunogen: PTBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human PTBP1. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FL WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Kanda, T., et al. J. Viral Hepat. 17(9):618-623(2010) Cobbold, L.C., et al. Oncogene 29(19):2884-2891(2010) Verma, B., et al. J. Gen. Virol. 91 (PT 5), 1245-1255 (2010) : Maynard, C.M., et al. J. Mol. Biol. 397(1):260-277(2010) Xue, Y., et al. Mol. Cell 36(6):996-1006(2009)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/19/040583-APC_1.jpg