antibody

PLAUR, ID (PLAUR, MO3, UPAR, Urokinase Plasminogen Activator Surface Receptor, Monocyte Activation Antigen Mo3, CD87)

040129

200 ul

polyclonal

domestic rabbit

nonconjugated

PLAUR, ID (PLAUR, MO3, UPAR, Urokinase Plasminogen Activator Surface Receptor, Monocyte Activation Antigen Mo3, CD87)

rabbit

Pab

Antibodies

200 ul

IgG

The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes. The human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion.1 It produces a highly glycosylated protein of about 50kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. PLAUR, also known as UPAR, is directly associated with the carbohydrate-binding domain of SELL in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins.2 PLAUR-mediated calcium mobilization is SELL dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas and show a 33-fold increase in UPAR mRNA levels in advanced clinical stage endometrial tumors compared with normal endometrial tissue.3 Furthermore, the increase in UPAR mRNA levels correlated linearly with the progression of disease stage. UPAR protein expressioin correlated positively with rate of recurrence and mortality in patients with endometrial cancer.4 UPAR appears to be a useful prognostic marker for advanced endometrial cancer. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:50-100 Immunohistochemistry: 1:50-100 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

PLAUR, MO3, UPAR, Urokinase Plasminogen Activator Surface Receptor, Monocyte Activation Antigen Mo3, CD87

PLAUR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human PLAUR.

Recognizes human PLAUR.

Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein G affinity chromatography. Immunogen: PLAUR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human PLAUR. Specificity: Recognizes human PLAUR. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E IHC WB

-20°C

1. Borgfeldt, C., et al., Int. J. Cancer 107(4): 658-665 (2003). 2. Tran, H., et al., Mol. Cell. Biol. 23(20): 7177-7188 (2003). 3. Coleman, J.L., et al., Infect. Immun. 71(10): 5556-5564 (2003). 4. Sturge, J., et al., J. Cell Biol. 162(5): 789-794 (2003). 5. Li, Y., et al., J. Biol. Chem. 278(32): 29,925-29,932 (2003).

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