PKC beta2, CT (PRKCB, PKCB, PRKCB1, Protein kinase C beta type) | US Biological 040091 product information

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product summary

company name :

US Biological

product type :

antibody

product name :

PKC beta2, CT (PRKCB, PKCB, PRKCB1, Protein kinase C beta type)

catalog :

040091

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

040091

Product wo Prefix :

PKC beta2, CT (PRKCB, PKCB, PRKCB1, Protein kinase C beta type)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC beta is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Isoform 1 uses an alternate exon at the 3' end compared to isoform 2, which includes a part of the coding region. The resulting isoform 1 has a distinct and shorter C-terminus, as compared to isoform 2. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mk Mo Rt

Alternate Name :

PRKCB, PKCB, PRKCB1, Protein kinase C beta type

Immunogen :

PKC beta2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 644~673 amino acids from the C-terminal region of human PKC beta2.

Specificity :

Human, monkey, mouse, rat

Purity :

Purified by Protein G affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein G affinity chromatography. Immunogen: PKC beta2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 644~673 amino acids from the C-terminal region of human PKC beta2. Specificity: Human, monkey, mouse, rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

-20°C

Reference :

Chen, D., et al., J. Biol. Chem. 279(6):4829-4839 (2004). Hug, B.A., et al., J. Biol. Chem. 279(2):825-830 (2004). Wu, H., et al., Biochem. Biophys. Res. Commun. 311(4):948-953 (2003). Becker, K.P., et al., J. Biol. Chem. 278(52):52747-52754 (2003). Birikh, K.R., et al., Proc. Natl. Acad. Sci. U.S.A. 100(1):283-288 (2003).

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/17/040091_1.jpg