antibody

PINK1, NT (T133) (PARK6, Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, PTEN-induced putative kinase protein 1)

040073

200 ul

polyclonal

domestic rabbit

nonconjugated

PINK1, NT (T133) (PARK6, Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, PTEN-induced putative kinase protein 1)

rabbit

Pab

Antibodies

200 ul

IgG

Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD. Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:50-100 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu Mo

PARK6, Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, PTEN-induced putative kinase protein 1

PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125~155 amino acids from the N-terminal region of human Park6 (PINK1).

Human, mouse

Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS. Immunogen: PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125~155 amino acids from the N-terminal region of human Park6 (PINK1). Specificity: Human, mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E IHC WB

-20°C

Rogaeva,E.,et al. Arch. Neurol. 61 (12), 1898-1904 (2004) Hatano,Y., et al. Ann. Neurol. 56 (3), 424-427 (2004) Healy,D.G., et al. Ann. Neurol. 56 (3), 329-335 (2004) Valente,E.M., et al. Science 304 (5674), 1158-1160 (2004) Nakajima,A., et al. Cancer Lett. 201 (2), 195-201 (2003) Unoki,M. and Nakamura,Y. Oncogene 20 (33), 4457-4465 (2001)

https://usbio-images.r.worldssl.net/prodimages/19/040073_1.jpg

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.