PAX5, ID (PAX5, Paired box protein Pax-5, B Cell-specific transcription factor)

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product summary

company name :

US Biological

product type :

antibody

product name :

PAX5, ID (PAX5, Paired box protein Pax-5, B Cell-specific transcription factor)

catalog :

039702

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

039702

Product wo Prefix :

PAX5, ID (PAX5, Paired box protein Pax-5, B Cell-specific transcription factor)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. Applications: Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Flow Cytometry: 1:10-50 Immunohistochemistry: 1:10-50 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

PAX5, Paired box protein Pax-5, B-cell-specific transcription factor

Immunogen :

PAX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-215 amino acids from the Central region of human PAX5.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: PAX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-215 amino acids from the Central region of human PAX5. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E FC IHC WB

Storage Temperature :

-20°C

Reference :

Song, J., et al. Arch. Pathol. Lab. Med. 134(11):1702-1705(2010) Okamoto, R., et al. Haematologica 95(9):1481-1488(2010) Best, A., et al. Leuk. Res. 34(8):1098-1102(2010) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Vidal, L.J., et al. Mol. Cancer Res. 8(3):444-456(2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/31/039702_1.jpg