antibody

PAX5, ID (PAX5, Paired box protein Pax-5, B Cell-specific transcription factor) (APC)

039702-APC

200 ul

polyclonal

domestic rabbit

APC

PAX5, ID (PAX5, Paired box protein Pax-5, B Cell-specific transcription factor) (APC)

rabbit

Pab

APC

Antibodies

200 ul

IgG

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. Applications: Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, FLISA Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Flow Cytometry: 1:10-50 Immunohistochemistry: 1:10-50 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu

PAX5, Paired box protein Pax-5, B-cell-specific transcription factor

PAX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-215 amino acids from the Central region of human PAX5.

Human

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A affinity chromatography. Immunogen: PAX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-215 amino acids from the Central region of human PAX5. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

FC FL IHC WB

4°C Do Not Freeze

Song, J., et al. Arch. Pathol. Lab. Med. 134(11):1702-1705(2010) Okamoto, R., et al. Haematologica 95(9):1481-1488(2010) Best, A., et al. Leuk. Res. 34(8):1098-1102(2010) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Vidal, L.J., et al. Mol. Cancer Res. 8(3):444-456(2010)

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