antibody

NXF1, NT (NXF1, TAP, Nuclear RNA export factor 1, Tip-associated protein, Tip-associating protein, mRNA export factor TAP) (AP)

039228-AP

200 ul

polyclonal

domestic rabbit

AP

NXF1, NT (NXF1, TAP, Nuclear RNA export factor 1, Tip-associated protein, Tip-associating protein, mRNA export factor TAP) (AP)

rabbit

Pab

AP

Antibodies

200 ul

IgG

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu

NXF1, TAP, Nuclear RNA export factor 1, Tip-associated protein, Tip-associating protein, mRNA export factor TAP

NXF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NXF1.

Human

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: NXF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NXF1. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E IHC WB

4°C Do Not Freeze

Read, E.K., et al. J. Gen. Virol. 91 (PT 5), 1290-1301 (2010) : Corbin-Lickfett, K.A., et al. J. Virol. 84(5):2212-2222(2010) Hautbergue, G.M., et al. Curr. Biol. 19(22):1918-1924(2009) Uranishi, H., et al. J. Biol. Chem. 284(38):26106-26116(2009) Ote, I., et al. PLoS ONE 4 (11), E7882 (2009) :

https://usbio-images.r.worldssl.net/prodimages/12/039228-AP_1.jpg