NR3C2, ID (NR3C2, MCR, MLR, Mineralocorticoid receptor, Nuclear receptor subfamily 3 group C member 2)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

NR3C2, ID (NR3C2, MCR, MLR, Mineralocorticoid receptor, Nuclear receptor subfamily 3 group C member 2)

catalog :

039130

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

039130

Product wo Prefix :

NR3C2, ID (NR3C2, MCR, MLR, Mineralocorticoid receptor, Nuclear receptor subfamily 3 group C member 2)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. Applications: Suitable for use in Western Blot and ELISA. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

NR3C2, MCR, MLR, Mineralocorticoid receptor, Nuclear receptor subfamily 3 group C member 2

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 654-683 in the central region of human NR3C2. Species Sequence Homology: mouse, rat, Xenopus

Specificity :

Recognizes human NR3C2.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As Reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 654-683 in the central region of human NR3C2. Species Sequence Homology: mouse, rat, Xenopus Specificity: Recognizes human NR3C2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. van Leeuwen, N., et al. Hypertension 56(5):995-1002 (2010). 2. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253 (2010). 3. Bouma, E.M., et al. Behav. Genet. (2010). 4. Bogdan, R., et al. Genes Brain Behav. 9(6):658-667 (2010). 5. Gu, D., et al. J. Hypertens. 28(6):1210-1220 (2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/10/039130_1.jpg