antibody

NOG, ID (NOG, Noggin)

039048

200 ul

polyclonal

domestic rabbit

nonconjugated

NOG, ID (NOG, Noggin)

rabbit

Pab

Antibodies

200 ul

IgG

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. Applications: Suitable for use in Western Blot and ELISA. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu Mo

NOG, Noggin

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 84-111 in the central region of human NOG, UniProt Accession #Q13253; NP_005441.1. Species Sequence Homology: rat

Recognizes human NOG. Species Crossreactivity: mouse

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

As Reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 84-111 in the central region of human NOG, UniProt Accession #Q13253; NP_005441.1. Species Sequence Homology: rat Specificity: Recognizes human NOG. Species Crossreactivity: mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E WB

-20°C

1. Rudnik-Schoneborn, S., et al. Am. J. Med. Genet. A 152A (6), 1540-1544 (2010) 2. Song, K., et al. J. Biol. Chem. 85(16):12169-12180(2010) 3. Mangold, E., et al. Nat. Genet. 42(1):24-26(2010) 4. Gutierrez, S.J., et al. Acta Odontol Latinoam 23(1):13-19(2010) 5. Zhao, J., et al. BMC Med. Genet. 11, 96 (2010)

https://usbio-images.r.worldssl.net/prodimages/9/039048_1.jpg