antibody

NOG, ID (NOG, Noggin) (APC)

039048-APC

200 ul

polyclonal

domestic rabbit

APC

NOG, ID (NOG, Noggin) (APC)

rabbit

Pab

APC

Antibodies

200 ul

IgG

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. Applications: Suitable for use in Western Blot, FLISA Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu Mo

NOG, Noggin

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 84-111 in the central region of human NOG, UniProt Accession #NP_005441.1; Q13253. Species sequence homology: rat

Recognizes human NOG. Species Crossreactivity: mouse

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 84-111 in the central region of human NOG, UniProt Accession #NP_005441.1; Q13253. Species sequence homology: rat Specificity: Recognizes human NOG. Species Crossreactivity: mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

FL WB

4°C Do Not Freeze

1. Rudnik-Schoneborn, S., et al. Am. J. Med. Genet. A 152A (6), 1540-1544 (2010) 2. Song, K., et al. J. Biol. Chem. 85(16):12169-12180(2010) 3. Mangold, E., et al. Nat. Genet. 42(1):24-26(2010) 4. Gutierrez, S.J., et al. Acta Odontol Latinoam 23(1):13-19(2010) 5. Zhao, J., et al. BMC Med. Genet. 11, 96 (2010)

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