NFKBIA, phosphorylated (Ser32) (NFKBIA, IKBA, MAD3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, Major histocompatibility complex enhancer-binding protein MAD3) (AP) | US Biological 038940-AP product information

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product summary

company name :

US Biological

product type :

antibody

product name :

NFKBIA, phosphorylated (Ser32) (NFKBIA, IKBA, MAD3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, Major histocompatibility complex enhancer-binding protein MAD3) (AP)

catalog :

038940-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

antigen modification :

phosphorylated

reactivity :

human

product information

Catalog Number :

038940-AP

Product wo Prefix :

NFKBIA, phosphorylated (Ser32) (NFKBIA, IKBA, MAD3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, Major histocompatibility complex enhancer-binding protein MAD3) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Antigen Modification :

phosphorylated

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime. Applications: Suitable for use in Dot Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Dot blot 1:500 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

NFKBIA, IKBA, MAD3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, Major histocompatibility complex enhancer-binding protein MAD3

Immunogen :

Phospho-NFKBIA (Ser32) antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between amino acids 20-50 surrounding S32 of human NFKBIA.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: Phospho-NFKBIA (Ser32) antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between amino acids 20-50 surrounding S32 of human NFKBIA. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

DB E

Storage Temperature :

4°C Do Not Freeze

Reference :

Wu, S., et al. J. Clin. Endocrinol. Metab. 95(3):1220-1228(2010) Senol Tuncay, S., et al. Biochem. Genet. 48 (1-2), 104-112 (2010) Hung, Y.H., et al. Dis. Markers 28(1):55-62(2010) McGeachie, M., et al. Circulation 120(24):2448-2454(2009)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/49/038940-AP_1.jpg