NF kappa B, phosphorylated (S536) (RELA, NFKB3, Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B Cells 3)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

NF kappa B, phosphorylated (S536) (RELA, NFKB3, Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B Cells 3)

catalog :

038926

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

product information

Catalog Number :

038926

Product wo Prefix :

NF kappa B, phosphorylated (S536) (RELA, NFKB3, Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B Cells 3)

Host :

rabbit

Product Type :

Pab

Antigen Modification :

phosphorylated

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). Applications: Suitable for use in Dot Blot and ELISA. Other applications have not been tested. Recommended Dilution: Dot blot: 1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

RELA, NFKB3, Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3

Immunogen :

KLH-conjugated synthetic phosphopeptide mapping to a fragment of residues surrounding S536 of human NF kappa B, Swiss/UniProt Accession: Q04206. Species sequence homology: mouse

Specificity :

Recognizes human NF kappa B.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic phosphopeptide mapping to a fragment of residues surrounding S536 of human NF kappa B, Swiss/UniProt Accession: Q04206. Species sequence homology: mouse Specificity: Recognizes human NF kappa B. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

DB E

Storage Temperature :

-20°C

Reference :

1. Pan, W.W., et al. J. Biol. Chem. 285(45):34348-34354(2010) 2. Tago, K., et al. J. Biol. Chem. 285(40):30622-30633(2010) 3. Park, J.S., et al. Oncol. Rep. 24(3):709-714(2010) 4. Yu, Z.H., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26(7):650-652(2010) 5. Rohwer, N., et al. PLoS ONE 5 (8), E12038 (2010) :

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/20/038926_1.png