NF kappa B (S276) (Nuclear factor of kappa light polypeptide gene enhancer in B Cells 3, Nuclear factor NF-kappa-B p65 subunit, Transcription factor p65, NFKB3, RELA)

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product summary

company name :

US Biological

product type :

antibody

product name :

NF kappa B (S276) (Nuclear factor of kappa light polypeptide gene enhancer in B Cells 3, Nuclear factor NF-kappa-B p65 subunit, Transcription factor p65, NFKB3, RELA)

catalog :

038922

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

038922

Product wo Prefix :

NF kappa B (S276) (Nuclear factor of kappa light polypeptide gene enhancer in B Cells 3, Nuclear factor NF-kappa-B p65 subunit, Transcription factor p65, NFKB3, RELA)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL(MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, Nuclear factor NF-kappa-B p65 subunit, Transcription factor p65, NFKB3, RELA

Immunogen :

NF kappa B-S276 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from human NF.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: NF kappa B-S276 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from human NF. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

Liu,J., et.al., J. Virol. 66 (6), 3883-3887 (1992)