antibody

MSR1, CT (MSR1, SCARA1, Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204) (AP)

038638-AP

200 ul

polyclonal

domestic rabbit

AP

MSR1, CT (MSR1, SCARA1, Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204) (AP)

rabbit

Pab

AP

Antibodies

200 ul

IgG

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu Mo

MSR1, SCARA1, Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 336-364 in the C-terminal region of human MSR1, UniProt Accession #NP_619729; P21757. Species Sequence Homology: bovine

Recognizes human MSR1. Species Crossreactivity: mouse

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 336-364 in the C-terminal region of human MSR1, UniProt Accession #NP_619729; P21757. Species Sequence Homology: bovine Specificity: Recognizes human MSR1. Species Crossreactivity: mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E WB

4°C Do Not Freeze

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010) Voruganti, V.S., et al. Am. J. Clin. Nutr. 91(6):1574-1583(2010) Nonomura, N., et al. Cancer Sci. 101(6):1570-1573(2010) Seizer, P., et al. Semin. Thromb. Hemost. 36(2):157-162(2010)

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