MMP13, ID (MMP13, Collagenase 3, Matrix metalloproteinase-13) (APC) | US Biological 038500-APC product information

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product summary

company name :

US Biological

product type :

antibody

product name :

MMP13, ID (MMP13, Collagenase 3, Matrix metalloproteinase-13) (APC)

catalog :

038500-APC

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

APC

reactivity :

human

product information

Catalog Number :

038500-APC

Product wo Prefix :

MMP13, ID (MMP13, Collagenase 3, Matrix metalloproteinase-13) (APC)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and FLISA. Other applications have not been tested. Recommended Dilutions: Immunohistochemistry: Formalin-fixed, paraffin-embedded sections Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

MMP13, Collagenase 3, Matrix metalloproteinase-13

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 253-282 in the central region of human MMP13, Species Sequence Homology: equine

Specificity :

Recognizes human MMP13.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Concentration :

As Reported

Calc Applications Abbrev :

FL IF IHC WB

Storage Temperature :

4°C Do Not Freeze

Reference :

1. Miranda, K.J., et al. J. Biol. Chem. 285(41):31517-31524(2010). 2. Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010). 3. Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010). 4. Yamada, T., et al. Anticancer Res. 30(7):2693-2699(2010). 5. Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/33/038500-APC_1.png