Metabotropic Glutamate Receptor 1, CT (GRM1, GPRC1A, MGLUR1, Metabotropic glutamate receptor 1)

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product summary

company name :

US Biological

product type :

antibody

product name :

Metabotropic Glutamate Receptor 1, CT (GRM1, GPRC1A, MGLUR1, Metabotropic glutamate receptor 1)

catalog :

038373

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

038373

Product wo Prefix :

Metabotropic Glutamate Receptor 1, CT (GRM1, GPRC1A, MGLUR1, Metabotropic glutamate receptor 1)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 (also known as GPRC1A) and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The activity of GRM1 is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. This protein may participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

GRM1, GPRC1A, MGLUR1, Metabotropic glutamate receptor 1

Immunogen :

GPRC1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1104~1133 amino acids from the C-terminal region of human GPRC1A.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: GPRC1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1104~1133 amino acids from the C-terminal region of human GPRC1A. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

-20°C

Reference :

Hlavackova, V., et al., EMBO J. 24(3):499-509 (2005). Kammermeier, P.J., et al., J. Pharmacol. Exp. Ther. 312(2):502-508 (2005). Burgueno, J., et al., Exp. Cell Res. 300(1):23-34 (2004). Mundell, S.J., et al., Mol. Pharmacol. 65(6):1507-1516 (2004). Anneser, J.M., et al., J. Neuropathol. Exp. Neurol. 63(8):831-840 (2004).

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/3/038373_1.jpg