MeCP2, phosphorylated (pS80) (MECP2, Methyl-CpG-binding protein 2)

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product summary

company name :

US Biological

product type :

antibody

product name :

MeCP2, phosphorylated (pS80) (MECP2, Methyl-CpG-binding protein 2)

catalog :

038314

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

product information

Catalog Number :

038314

Product wo Prefix :

MeCP2, phosphorylated (pS80) (MECP2, Methyl-CpG-binding protein 2)

Host :

rabbit

Product Type :

Pab

Antigen Modification :

phosphorylated

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Applications: Suitable for use in Dot Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Dot Blot 1:50-100 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

MECP2, Methyl-CpG-binding protein 2

Immunogen :

Phospho-MeCP2-pS80 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S80 of human MECP2.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: Phospho-MeCP2-pS80 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S80 of human MECP2. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

DB E

Storage Temperature :

-20°C

Reference :

Mnatzakanian, G.N., et al., Nat. Genet. 36(4):339-341 (2004). Laccone, F., et al., Hum. Mutat. 23(3):234-244 (2004). Suzuki, M., et al., Oncogene 22(54):8688-8698 (2003). Balmer, D., et al., J. Mol. Med. 81(1):61-68 (2003). Hagberg, B., et al., Eur. J. Paediatr. Neurol. 7(6):417-421 (2003).

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/29/038314_1.jpg