MeCP2, NT (S80) (MECP2, Methyl-CpG-binding protein 2) (AP) | US Biological 038313-AP product information

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product summary

company name :

US Biological

product type :

antibody

product name :

MeCP2, NT (S80) (MECP2, Methyl-CpG-binding protein 2) (AP)

catalog :

038313-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

reactivity :

human

product information

Catalog Number :

038313-AP

Product wo Prefix :

MeCP2, NT (S80) (MECP2, Methyl-CpG-binding protein 2) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq]. Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:50-100 1:10-50 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

MECP2, Methyl-CpG-binding protein 2

Immunogen :

MeCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MeCP2.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: MeCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MeCP2. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Shapiro, J.R., et al. Pediatr. Res. 68(5):446-451(2010) Pintaudi, M., et al. Epilepsy Behav (2010) In press : Jain, D., et al. Pediatr. Neurol. 43(1):35-40(2010) Harvey, C.G., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (3), 355-360 (2007) : Francke, U. Nat Clin Pract Neurol 2(4):212-221(2006)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/28/038313-AP_1.jpg