MAP2, phosphorylated (S1539) (MAP2, Microtubule-associated protein 2) (AP) | US Biological 038124-AP product information

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product summary

company name :

US Biological

product type :

antibody

product name :

MAP2, phosphorylated (S1539) (MAP2, Microtubule-associated protein 2) (AP)

catalog :

038124-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

antigen modification :

phosphorylated

reactivity :

human

product information

Catalog Number :

038124-AP

Product wo Prefix :

MAP2, phosphorylated (S1539) (MAP2, Microtubule-associated protein 2) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Antigen Modification :

phosphorylated

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2; two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton. Applications: Suitable for use in Dot Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Dot blotting 1:100-500 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

MAP2, Microtubule-associated protein 2

Immunogen :

Phospho-MAP2-S1539 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 1524~1553 amino acids surrounding S1539 of human MAP2.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: Phospho-MAP2-S1539 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 1524~1553 amino acids surrounding S1539 of human MAP2. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

DB E

Storage Temperature :

4°C Do Not Freeze

Reference :

Maddodi,N., et.al., J. Biol. Chem. 285 (1), 242-254 (2010) Krishnan,C., et.al., Am. J. Surg. Pathol. 33 (11), 1695-1704 (2009)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/31/038124-AP_1.jpg