LGMN, NT (LGMN, PRSC1, Legumain, Asparaginyl endopeptidase, Protease, cysteine 1)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

LGMN, NT (LGMN, PRSC1, Legumain, Asparaginyl endopeptidase, Protease, cysteine 1)

catalog :

037755

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

037755

Product wo Prefix :

LGMN, NT (LGMN, PRSC1, Legumain, Asparaginyl endopeptidase, Protease, cysteine 1)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. Applications: Suitable for use in Western Blot and ELISA. Other applications have not been tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

LGMN, PRSC1, Legumain, Asparaginyl endopeptidase, Protease, cysteine 1

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 83-112 in the N-terminal region of human LGMN, UniProt Accession: #Q99538. Species sequence homology: monkey

Specificity :

Recognizes human LGMN.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 83-112 in the N-terminal region of human LGMN, UniProt Accession: #Q99538. Species sequence homology: monkey Specificity: Recognizes human LGMN. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

Clerin, V., et al. Atherosclerosis 201(1):53-66(2008) Liu, Z., et al. Mol. Cell 29(6):665-678(2008) Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005) Dusso, A.S., et al. Am. J. Physiol. Renal Physiol. 289 (1), F8-F28 (2005) : Murthy, R.V., et al. Clin. Cancer Res. 11(6):2293-2299(2005)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/18/037755_1.jpg