antibody

KLRC1, NT (KLRC1, NKG2A, NKG2-A/NKG2-B type II integral membrane protein, CD159 antigen-like family member A, NK cell receptor A, NKG2-A/B-activating NK receptor, CD159a)

037578

200 ul

polyclonal

domestic rabbit

nonconjugated

KLRC1, NT (KLRC1, NKG2A, NKG2-A/NKG2-B type II integral membrane protein, CD159 antigen-like family member A, NK cell receptor A, NKG2-A/B-activating NK receptor, CD159a)

rabbit

Pab

Antibodies

200 ul

IgG

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. Applications: Suitable for use in Western Blot and Immunofluorescence. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Immunofluorescence: 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

KLRC1, NKG2A, NKG2-A/NKG2-B type II integral membrane protein, CD159 antigen-like family member A, NK cell receptor A, NKG2-A/B-activating NK receptor, CD159a

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa1-30 in the N-terminal region of human KLRC1, UniProt Accession #P26715; NP_998822.1; NP_002250.1; NP_015567.1; NP_998823.1 Cellular Localization: Membrane; Single-pass type II membrane protein

Recognizes human KLRC1 at ~26kD.

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

As Reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa1-30 in the N-terminal region of human KLRC1, UniProt Accession #P26715; NP_998822.1; NP_002250.1; NP_015567.1; NP_998823.1 Cellular Localization: Membrane; Single-pass type II membrane protein Specificity: Recognizes human KLRC1 at ~26kD. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

IF WB

-20°C

1. Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010). 2. Ma, J., et al. J. Med. Virol. 82(9):1501-1507(2010). 3. Harrison, R.J., et al. Clin. Exp. Immunol. 161(2):306-314(2010). 4. Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010). 5. Beziat, V., et al. PLoS ONE 5 (8), E11966 (2010) :

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