JAK1, CT (Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1, JAK1A) (APC) | US Biological 037175-APC product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

JAK1, CT (Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1, JAK1A) (APC)

catalog :

037175-APC

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

APC

reactivity :

human

product information

Catalog Number :

037175-APC

Product wo Prefix :

JAK1, CT (Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1, JAK1A) (APC)

Host :

rabbit

Product Type :

Pab

Conjugate :

APC

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. Applications: Suitable for use in Immunohistochemistry, FLISA Recommended Dilution: FLISA: 1:1,000 IHC1:100-500 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Hu Mo

Alternate Name :

Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1, JAK1A

Immunogen :

JAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1112~1142 amino acids from the C-terminal region of human JAK1.

Specificity :

Human, mouse

Purity :

Purified by Protein G affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein G affinity chromatography. Immunogen: JAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1112~1142 amino acids from the C-terminal region of human JAK1. Specificity: Human, mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FL IHC

Storage Temperature :

4°C Do Not Freeze

Reference :

Yokota, S., et al., Virology 306(1):135-146 (2003). Usacheva, A., et al., J. Biol. Chem. 277(50):48220-48226 (2002). Radtke, S., et al., J. Biol. Chem. 277(13):11297-11305 (2002). Muller, M., et al., Nature 366(6451):129-135 (1993). Howard, O.M., et al., Oncogene 7(5):895-900 (1992).