antibody

INHBB, CT (INHBB, Inhibin beta B chain, Activin beta-B chain)

037050

200 ul

polyclonal

domestic rabbit

nonconjugated

INHBB, CT (INHBB, Inhibin beta B chain, Activin beta-B chain)

rabbit

Pab

Antibodies

200 ul

IgG

The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Applications: Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications not tested. Recommended Dilution: Western Blot: 1:4000 Immunohistochemistry: 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu Mo

INHBB, Inhibin beta B chain, Activin beta-B chain

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa369-397 in the C-terminal region of human INHBB, Species sequence homology: bovine, chicken, porcine, rat. Swiss/UniProt Accession: P09529.

Recognizes human INHBB. Species Crossreactivity: mouse

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: mouse Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa369-397 in the C-terminal region of human INHBB, Species sequence homology: bovine, chicken, porcine, rat. Swiss/UniProt Accession: P09529. Specificity: Recognizes human INHBB. Species Crossreactivity: mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E IHC WB

-20°C

Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010) Ewens, K.G., et al. J. Clin. Endocrinol. Metab. 95(5):2306-2315(2010) Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) : Ahn, J., et al. Hum. Mol. Genet. 18(19):3749-3757(2009) Makanji, Y., et al. Endocrinology 150(10):4784-4793(2009)

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Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue using 037050 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of 037050 for immunohistochemistry.