antibody

INHBA, NT (INHBA, Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein)

037049

200 ul

polyclonal

domestic rabbit

nonconjugated

INHBA, NT (INHBA, Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein)

rabbit

Pab

Antibodies

200 ul

IgG

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot, Immunofluorescence and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Flow Cytometry: 1:10-1:50 Immunohistochemistry (FFPE): 1:10-1:50 Immunofluorescence: 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

INHBA, Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 85-112 in the N-terminal region of human INHBA. Species sequence homology: bovine, mouse, rat, sheep, equine

Recognizes human INHBA.

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 85-112 in the N-terminal region of human INHBA. Species sequence homology: bovine, mouse, rat, sheep, equine Specificity: Recognizes human INHBA. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E FC IF IHC WB

-20°C

1. Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010) 2. Shi, F.T., et al. J. Clin. Endocrinol. Metab. 95 (10), E172-E180 (2010) 3. Lascorz, J., et al. Carcinogenesis 31(9):1612-1619(2010) 4. Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) 5. Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010)

https://usbio-images.r.worldssl.net/prodimages/9/037049_1.jpg

Flow Cytometry analysis of CEM cells using 037049 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.