antibody

INHBA, NT (INHBA, Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein) (AP)

037049-AP

200 ul

polyclonal

domestic rabbit

AP

INHBA, NT (INHBA, Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein) (AP)

rabbit

Pab

AP

Antibodies

200 ul

IgG

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. Applications: Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications not tested. Recommended Dilutions: Immunohistochemistry: Formalin-fixed, paraffin-embedded sections Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu

INHBA, Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 85-112 in the N-terminal region of human INHBA. Species sequence homology: bovine, mouse, rat, sheep, equine

Recognizes human INHBA.

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 85-112 in the N-terminal region of human INHBA. Species sequence homology: bovine, mouse, rat, sheep, equine Specificity: Recognizes human INHBA. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E IHC WB

4°C Do Not Freeze

1. Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010) 2. Shi, F.T., et al. J. Clin. Endocrinol. Metab. 95 (10), E172-E180 (2010) 3. Lascorz, J., et al. Carcinogenesis 31(9):1612-1619(2010) 4. Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) 5. Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010)

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