antibody

HNRNPA1, CT (HNRNPA1, HNRPA1, Heterogeneous nuclear ribonucleoprotein A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1)

036658

200 ul

polyclonal

domestic rabbit

nonconjugated

HNRNPA1, CT (HNRNPA1, HNRPA1, Heterogeneous nuclear ribonucleoprotein A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1)

rabbit

Pab

Antibodies

200 ul

IgG

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq]. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

HNRNPA1, HNRPA1, Heterogeneous nuclear ribonucleoprotein A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1

HNRNPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human HNRNPA1.

Human

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: HNRNPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human HNRNPA1. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E WB

-20°C

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Michlewski, G., et al. Nat. Struct. Mol. Biol. 17(8):1011-1018(2010) Clower, C.V., et al. Proc. Natl. Acad. Sci. U.S.A. 107(5):1894-1899(2010) David, C.J., et al. Nature 463(7279):364-368(2010) Fisette, J.F., et al. RNA 16(1):228-238(2010)

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