HLA-C, ID (HLA-C, HLAC, HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

HLA-C, ID (HLA-C, HLAC, HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7)

catalog :

036617

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

036617

Product wo Prefix :

HLA-C, ID (HLA-C, HLAC, HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described Applications: Suitable for use in Western Blot and ELISA. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

HLA-C, HLAC, HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 66-93 in the central region of human HLA-C, Swiss/UniProt Accession: P10321

Specificity :

Recognizes human HLA-C.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As Reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 66-93 in the central region of human HLA-C, Swiss/UniProt Accession: P10321 Specificity: Recognizes human HLA-C. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Martin, M.P., et al. Immunogenetics 62 (11-12), 761-765 (2010) 2. Strange, A., et al. Nat. Genet. 42(11):985-990(2010) 3. Noble, J.A., et al. Diabetes 59(11):2972-2979(2010) 4. Honeyborne, I., et al. J. Virol. 84(21):11279-11288(2010) 5. Healy, B.C., et al. Neurology 75(7):634-640(2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/3/036617_1.png