antibody

HLA-C, ID (HLA-C, HLAC, HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7) (APC)

036617-APC

200 ul

polyclonal

domestic rabbit

APC

HLA-C, ID (HLA-C, HLAC, HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7) (APC)

rabbit

Pab

APC

Antibodies

200 ul

IgG

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described Applications: Suitable for use in Western Blot and FLISA. Other applications have not been tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu

HLA-C, HLAC, HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 66-93 in the central region of human HLA-C, Swiss/UniProt Accession: P10321

Recognizes human HLA-C.

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

As Reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 66-93 in the central region of human HLA-C, Swiss/UniProt Accession: P10321 Specificity: Recognizes human HLA-C. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

FL WB

4°C Do Not Freeze

1. Martin, M.P., et al. Immunogenetics 62 (11-12), 761-765 (2010) 2. Strange, A., et al. Nat. Genet. 42(11):985-990(2010) 3. Noble, J.A., et al. Diabetes 59(11):2972-2979(2010) 4. Honeyborne, I., et al. J. Virol. 84(21):11279-11288(2010) 5. Healy, B.C., et al. Neurology 75(7):634-640(2010)

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