HFE2, CT (HFE2, HJV, RGMC, Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

HFE2, CT (HFE2, HJV, RGMC, Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C)

catalog :

036528

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

036528

Product wo Prefix :

HFE2, CT (HFE2, HJV, RGMC, Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. Applications: Suitable for use in Western Blot and Flow Cytometry. Other applications have not been tested. Recommended Dilution: Western Blot: 1:1000 Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Alternate Name :

HFE2, HJV, RGMC, Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C

Immunogen :

Synthetic peptide corresponding to a portion of amino acids within aa308-338 from the C-terminal region of human HFE2, conjugated to KLH (Q6ZVN8). Species sequence homology: mouse, rat

Specificity :

Recognizes human HFE2.

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: Synthetic peptide corresponding to a portion of amino acids within aa308-338 from the C-terminal region of human HFE2, conjugated to KLH (Q6ZVN8). Species sequence homology: mouse, rat Specificity: Recognizes human HFE2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FC WB

Storage Temperature :

-20°C

Reference :

1. Zhu, X., et al. Genet. Epidemiol. 34(2):171-187(2010) 2. Barton, J.C., et al. Am. J. Hematol. 84(11):710-714(2009) 3. Zhang, A.S., et al. J. Biol. Chem. 284(34):22580-22589(2009)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/10/036528_1.jpg