HFE2, CT (HFE2, HJV, RGMC, Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C) (AP) | US Biological 036528-AP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

HFE2, CT (HFE2, HJV, RGMC, Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C) (AP)

catalog :

036528-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

reactivity :

human

product information

Catalog Number :

036528-AP

Product wo Prefix :

HFE2, CT (HFE2, HJV, RGMC, Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 1:10-50 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

HFE2, HJV, RGMC, Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C

Immunogen :

HFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acids 520-550 from the C-terminal region of human HFE2.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: HFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acids 520-550 from the C-terminal region of human HFE2. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Zhu, X., et al. Genet. Epidemiol. 34(2):171-187(2010) Barton, J.C., et al. Am. J. Hematol. 84(11):710-714(2009) Zhang, A.S., et al. J. Biol. Chem. 284(34):22580-22589(2009)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/15/036528-AP_1.jpg