antibody

GSTM5, NT (GSTM5, Glutathione S-transferase Mu 5, GST class-mu 5, GSTM5-5) (AP)

036341-AP

200 ul

polyclonal

domestic rabbit

AP

GSTM5, NT (GSTM5, Glutathione S-transferase Mu 5, GST class-mu 5, GSTM5-5) (AP)

rabbit

Pab

AP

Antibodies

200 ul

IgG

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Applications: Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested. Recommended Dilution: Immunohistochemistry: Formalin-fixed, paraffin-embedded sections Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu

GSTM5, Glutathione S-transferase Mu 5, GST class-mu 5, GSTM5-5

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 14-43 from the N-terminal region of human GSTM5.

Recognizes human GSTM5.

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 14-43 from the N-terminal region of human GSTM5. Specificity: Recognizes human GSTM5. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E IHC WB

4°C Do Not Freeze

1. Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010) 2. Yu, K.D., et al. Breast Cancer Res. Treat. 121(2):485-496(2010) 3. Davila, S., et al. Genes Immun. 11(3):232-238(2010) 4. Moyer, A.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(3):811-821(2010) 5. Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)

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