GRM1, CT (GRM1, GPRC1A, MGLUR1, Metabotropic glutamate receptor 1) (AP) | US Biological 036313-AP product information

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product summary

company name :

US Biological

product type :

antibody

product name :

GRM1, CT (GRM1, GPRC1A, MGLUR1, Metabotropic glutamate receptor 1) (AP)

catalog :

036313-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

reactivity :

human

product information

Catalog Number :

036313-AP

Product wo Prefix :

GRM1, CT (GRM1, GPRC1A, MGLUR1, Metabotropic glutamate receptor 1) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq]. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

GRM1, GPRC1A, MGLUR1, Metabotropic glutamate receptor 1

Immunogen :

GRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1094-1123 amino acids from the C-terminal region of human GRM1.

Specificity :

Human

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: GRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1094-1123 amino acids from the C-terminal region of human GRM1. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Jiang, Y., et al. J. Biol. Chem. 285(43):33463-33474(2010) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Gong, P., et al. J. Mol. Neurosci. 42(1):120-126(2010) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Boer, K., et al. Brain Res. 1324, 24-33 (2010) :

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/22/036313-AP_1.jpg