GAD2, ID (GAD2, GAD65, Glutamate decarboxylase 2, 65kD glutamic acid decarboxylase, Glutamate decarboxylase 65kD isoform) (AP) | US Biological 035868-AP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

GAD2, ID (GAD2, GAD65, Glutamate decarboxylase 2, 65kD glutamic acid decarboxylase, Glutamate decarboxylase 65kD isoform) (AP)

catalog :

035868-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

reactivity :

human

product information

Catalog Number :

035868-AP

Product wo Prefix :

GAD2, ID (GAD2, GAD65, Glutamate decarboxylase 2, 65kD glutamic acid decarboxylase, Glutamate decarboxylase 65kD isoform) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. Applications: Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

GAD2, GAD65, Glutamate decarboxylase 2, 65kD glutamic acid decarboxylase, Glutamate decarboxylase 65kD isoform

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 109-138 in the Central region of human GAD2, UniProt Accession #Q05329. Species Sequence Homology: Mouse, rat, porcine.

Specificity :

Recognizes human GAD2.

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 109-138 in the Central region of human GAD2, UniProt Accession #Q05329. Species Sequence Homology: Mouse, rat, porcine. Specificity: Recognizes human GAD2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E IHC WB

Storage Temperature :

4°C Do Not Freeze

Reference :

1. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) 2. Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) 3. Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010) 4. Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) 5. Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/44/035868-AP_1.pdf