FOLR2, NT (FOLR2, Folate receptor beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein)

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product summary

company name :

US Biological

product type :

antibody

product name :

FOLR2, NT (FOLR2, Folate receptor beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein)

catalog :

035714

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

035714

Product wo Prefix :

FOLR2, NT (FOLR2, Folate receptor beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

FOLR2 is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Applications: Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry and ELISA. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo

Alternate Name :

FOLR2, Folate receptor beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein

Immunogen :

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 18-46 of human FOLR2.

Specificity :

Recognizes human FOLR2. Species Crossreactivity: mouse

Purity :

Purified by Protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Concentration :

As Reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 18-46 of human FOLR2. Specificity: Recognizes human FOLR2. Species Crossreactivity: mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E FC IHC WB

Storage Temperature :

-20°C

Reference :

1. Puig-Kroger, A., et al. Cancer Res. 69(24):9395-9403(2009). 2. Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009). 3. Franke, B., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 85(3):216-226(2009)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/36/035714_1.jpg

Picture4 Text :

Immunohistochemical staining of formalin fixed, paraffin-embedded human spleen using 035714. HRP-conjugated secondary antibody and DAB staining were used for visualizaton of antigen.

Picture 5 File Name :

https://usbio-images.r.worldssl.net/prodimages/36/035714_5.jpg

Picture5 Text :

Flow Cytometric analysis of HL-60 cells using 035714 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibody was used for the analysis.