antibody

FGFRL1, NT (FGFRL1, FGFR5, FHFR, Fibroblast growth factor receptor-like 1, FGF homologous factor receptor, FGFR-like protein, Fibroblast growth factor receptor 5) (AP)

035644-AP

200 ul

polyclonal

domestic rabbit

AP

FGFRL1, NT (FGFRL1, FGFR5, FHFR, Fibroblast growth factor receptor-like 1, FGF homologous factor receptor, FGFR-like protein, Fibroblast growth factor receptor 5) (AP)

rabbit

Pab

AP

Antibodies

200 ul

IgG

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu

FGFRL1, FGFR5, FHFR, Fibroblast growth factor receptor-like 1, FGF homologous factor receptor, FGFR-like protein, Fibroblast growth factor receptor 5

FGFRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-168 amino acids from the N-terminal region of human FGFRL1.

Human

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: FGFRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-168 amino acids from the N-terminal region of human FGFRL1. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E IHC WB

4°C Do Not Freeze

Bailey, S.D., et al. Diabetes Care (2010) In press : Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010) LopezJimenez, N., et al. Hum. Genet. 127(3):325-336(2010) Steinberg, F., et al. J. Biol. Chem. 285(3):2193-2202(2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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