ERCC1, CT (ERCC1, DNA excision repair protein ERCC-1) (APC) | US Biological 035194-APC product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

ERCC1, CT (ERCC1, DNA excision repair protein ERCC-1) (APC)

catalog :

035194-APC

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

APC

reactivity :

human

product information

Catalog Number :

035194-APC

Product wo Prefix :

ERCC1, CT (ERCC1, DNA excision repair protein ERCC-1) (APC)

Host :

rabbit

Product Type :

Pab

Conjugate :

APC

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. Applications: Suitable for use in Western Blot, FLISA Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Hu Mo

Alternate Name :

ERCC1, DNA excision repair protein ERCC-1

Immunogen :

ERCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-297 amino acids from the C-terminal region of human ERCC1.

Specificity :

Human, mouse

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A affinity chromatography. Immunogen: ERCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-297 amino acids from the C-terminal region of human ERCC1. Specificity: Human, mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

FL WB

Storage Temperature :

4°C Do Not Freeze

Reference :

Palli, D., et al. Mutagenesis 25(6):569-575(2010) Scheil-Bertram, S., et al. Gynecol. Oncol. 119(2):325-331(2010) Wenchao, L., et al. Diagn. Mol. Pathol. 19(3):164-168(2010) Hoffmann, A.C., et al. Neoplasia 12(8):628-636(2010) van Duin, M., et al. Mol. Cell. Biol. 9(4):1794-1798(1989)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/27/035194-APC_1.jpg