ERBB2, phosphorylated (S1114) (Erbb2, Kiaa3023, Neu, Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340) (AP) | US Biological 035169-AP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

ERBB2, phosphorylated (S1114) (Erbb2, Kiaa3023, Neu, Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340) (AP)

catalog :

035169-AP

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

antigen modification :

phosphorylated

reactivity :

mouse

product information

Catalog Number :

035169-AP

Product wo Prefix :

ERBB2, phosphorylated (S1114) (Erbb2, Kiaa3023, Neu, Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340) (AP)

Host :

rabbit

Product Type :

Pab

Conjugate :

Antigen Modification :

phosphorylated

Category :

Antibodies

Size1 :

200 ul

Isotype :

IgG

Desc1 :

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. Applications: Suitable for use in Dot Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Dot blot 1:500 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Calc Crossreactivity :

Alternate Name :

Erbb2, Kiaa3023, Neu, Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340

Immunogen :

mouse ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1114 of mouse ERBB2.

Specificity :

Mouse

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

Concentration :

As reported

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: mouse Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: mouse ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1114 of mouse ERBB2. Specificity: Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

DB E

Storage Temperature :

4°C Do Not Freeze

Reference :

Cabodi, S., et al. FASEB J. 24(10):3796-3808(2010) Johnson, E., et al. J. Biol. Chem. 285(38):29491-29501(2010) Huck, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15559-15564(2010) Chuang, T.D., et al. J. Biol. Chem. 285(31):23598-23606(2010) Simeone, L., et al. J. Neurosci. 30(19):6620-6634(2010)

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/22/035169-AP_1.jpg